How about B5 (that's "Babylon 5" for those who've been away from Earth for the last ten or so years)? That universe could acommodate a whole host of different adventure games, detective games, RPGs, action games and flight games. It's full of interesting stories, sideplots that would benefit from being explored in more detail and all the other stuff that makes a good foundation for all sorts of computer games.
Also it'd be interesting to see how a Marvel / DC character or group (who are mostly action heroes) would translate into adventure games. DC tried it with Batman, but I'd like to see some Marvel hero in an adventure game too.
It is pitch black. You are likely to be eaten by a grue.
<insert pleasantly understated Sam & Max quote here>