well, i would like to see a new graphics engine implemented for realism's sake, but i would be extremely dissappointed to find the core combat and overall gameplay engine changed drastically.
also, i agree with Darth333 on the influence point. having a completely dark Handmaiden scold you for killing someone is just stupid. she should be agreeing with you.
allow whoever develops the game to take their time to actually complete the game in a manner that makes the game complete in terms of the ending and overall polish.
otherwise, my list doesn't extend too awefully long. *shrugs*
See the struggle of the faithless lot as they negate their time
How low to sink to the depths of their frame of mind