Where Chepito just walk off into the next world...made me think, "wow, that guy sure has guts"
Also when Olivia betrays you..i always thought she was reliable upto that point and i was just like "no you killed Salvador!" then Salvador sacrifices himself, which is sad...but he does away with Olivia at the same time!
The bit where manny uncovers Salvador's body is also very moving. Manny just keeps that same facial expression while he unearths him.
And of course, the end was very emotional. Because its a tear jerking scene and its the end of the best game ever.