Well, there was one time my entire inventory disappeared. After I noticed it, I just replaced the items I could remember via a saved game editor (KSE), but every time I tried to get off the Ebon Hawk on Dantooine, the game crashed. It never happened again, and I never found out what triggered it, but it ruined the game, so I had to start over.
One thing that fools will never understand is that only a weakling lets the darkness control him. A mix of light and darkness is a powerful thing. Volatile, yes, but also unexpected, and thus even more dangerous.