Originally Posted by Marauder's Fury
I've made some minor changes in the spells.2da file, but KSE wouldn't seem to agree with it. Then I've abandoned it and downloaded a mod named "Ultimate Sound Mod", causing the same problem.
What exactly is the symptom? Does it give an error message like "Attempted to read past the end of dialog.tlk" or something similar? Does it close instantly?
Take a look at this thread first.
You can get a lot more information about what exactly is causing KSE to crash if you follow the steps under the "Troubleshooting Other Problems" header at the bottom of that thread.