I got through it. *Warning: noob comment* I forgot to give my characters any talent points, since they were already at level 3 and I had no idea!
Anyway, the only thing difficult battle I've encountered is against the Krogan Battlemaster on the planet where you save Liara. I think I've done that 15 times before just switching difficulty to casual and ending it rather quickly. The fact that the guy rushes to you and can kill you with two melee hits of his weapon is frustrating, even more so if you thought disabling his biotics would make him an easy target.