If you use mods, or even just pick up stuff at random, sometimes you pick up some nice equipment to use in unarmed combat. However, myself, once I get things right, I just use stealth and use dominate mind, I think. Whichever of the force powers allows me to make one enemy into one of my allies, for a short while. It's fun collecting the xp from them, until they get themselves kilt.
When everything else fails, CHEAT!