It's hard to say. To me, it just sounds like Lucas wants Anakin/Vader to be THE most powerful force user of all time. As such, he just makes him good at everything which gives him the appeal similar to Superman. He probably would kill her.
The Exile would know better than to fight him head on anyways. As to what exactly she would do, I have no idea... which is ironic, because I usually decide what she does. I'd/she'd probably just put down a bunch of devastating frag mines before the battle. And since it is TSL, the battle will probably be too easy and unbalanced
I think we can agree that the Exile would definitely kill Episode IV Vader, right?