Ok I am at my wits end with KoTOR.
MSI x58 Platinum
EVGA GTX 280
Vista Home Premium 64, SP 1
Legit copy of KoTOR, installed in XP SP2 Compatibility mode, ran patch program (also in compatibility). Got the Direct X 9 patch suggested in this thread, set processor affinity to core 0 (each freaking time). I have no haks or mods installed.
I keep crashing at various places, had all video settings maxed out, so dropped them all to min. (ugly and cased problems with walkmesh/walking with my PC)
Current site of crashing is in the crystal cave on Dantooie.