I remember trying Fallout 3 when it first came out. Felt the same way about it that I felt about the first two Fallouts: This game would be twice as interesting in a different setting.
But I actually just rebooted the game earlier this week with a crap-load of mods. I found a save game that dropped me right outside vault 101 so I didn't have to go through that boring exposition level again, and I'm actually having fun doing the side-quests and whatnot. I don't think I'll do the main quest, though. I didn't like it very much the first time around.