I think if they can do it right it could be an amazing game. I just think about the how large they could make the game world instead of focusing on just a small portion of the U.S. they could even expand to Europe or up into Canada and what not. They could even incorporate settlements from the Fallout Trilogy so you can see how they've progressed since the events of the games. The potential is there if they can do it right.
"You'll find that many of the truths we cling to depend greatly on our own point of view."