I've enjoyed what I've played so far (about 5 hours or so), but a few things have annoyed me a little.
The story doesn't seem to get off to a great start - or at least, I didn't think it did - it wasn't particularly clear, and in some cases it felt like I was simply stumbling into things.
It's picked up a little since I've reached Vegas, although I was a little confused when
A woman approached me after meeting with Mr. House, and asked If i'd reconsidered their request to bug his network - I'd never seen her before.
I've also noticed that there seems to be a lack of variety with merchants - I'd never expected to be buying much from them in the first place, but I can't see the point in buying from any at all when they all seem to have near-identical stock.
And, as much as I love Dean Martin and Bing Crosby, I'm sick of hearing the same three songs over and over. And over.
Despite those niggles (no crashes yet, either) I am enjoying it more than FO3, even if my vendor still hasn't e-mailed my pre-order bonus codes.