Well I hate to be that guy who injects a bit of positivity into what is otherwise a round-bollocking session, but i thought the
mission to cure the Genophage on Tuchanka was one of the most intense gaming sequences I've ever had to pleasure of playing, starting in those deep catacombs, onto the bit where you're running around not knowing what the **** is going on because of all those brutes and then when the cure is actually injected and the beautiful sequence that follows. I was floored. Going back there armed with fraps for some screenshots ASAP.
Kind of annoyed with myself that I annoyed Liara by utterly failing to resist the temptation to jump into the shower with Samantha Traynor.
Also slightly annoyed that my N7 rank from the demo didn't pass along into the multiplayer, but ho-hum