Saw it yesterday.
It was my first movie of the Alien/Predator/Alien vs. Predator franchise, and in that regard, I probably should have watched Alien or something before seeing Prometheus, but I knew nothing about Prometheus when I went to see it.
I liked the movie, but I think some of the 'horror' aspects of the plot were caused by sheer stupidity on the characters' part, eg, leaving no one to monitor comms while two of the crew are trapped inside a giant freaking alien tomb. I know the prospect of sex was to blame, but it wouldn't take much effort to just order one lackey to watch the system while you went to get jiggy.
Also: getting squished by a giant rolling ship. Run to the side, damnit!
There are also some things that I might have missed/don't understand/might be plotholes:
1. The crew told the scientists that the silt in the storm could have destroyed their suits. Why didn't it?
2. Why the hell did David poison Charlie with the goo?? Did he know what was going to happen, or was it out of some morbid curiosity?
3. Did Elizabeth know that David was the one to get Charlie sick? It seemed like it in the end.. If so, she seemed awfully calm/not angry with him/the idea of teaming up with the guy/thing that caused the death of her lover..
I liked Noomi Rapace's performance as Dr. Shaw, and Michael Fassbender's as David.
It's your run of the mill scientific-expedition-gone-wrong story, but I liked it. Will certainly go to see a sequel if one is released.