Originally Posted by DarthParametric
Zbrush is a sculpting program (as are Mudbox and other similar programs). They are used to make a high poly mesh to generate normal maps. You still do all your low poly rigging in a traditional 3D app like Max or Maya.
Indeed, and high poly baking is now the industry standard. If you want to do characters in the industry, you will more likely than not need to know how to use Zbrush or Mudbox. And yes, you would also need a normal modeling program such as 3DS Max to be used in conjunction. I would not recommend touching Zbrush until you're proficient in 3DS Max, I probably should have added that.