As we all probably know, Windows Vista was released under a week ago. While efforts were made on Microsoft's part to keep compatibility to a maximum, I fear Grim Fandango will have problems just like it did/does with Windows 2000 and XP.
The question is, does Grim Fandango have problems when running on Windows Vista (eg: lag like on XP, etc), or does it outright refuse to run?
If the latter is the case, oh dear.
Hopefully it'll be enough to stir the ScummVM/Residual guys into action and get it working or something.